When did the Holy Roman Empire collapse?

There is a presumption here that "Germany", "France", and "Italy" existed long before unification -- which result was, again a presumption, some good thing. The 20th century demonstrated quite the contrary. France arrogantly tried to remake the map of Europe, Germany twice tried to impose its will on the rest of Europe, and Italy invaded Africa. The success story was Britain which won by losing. Even from a modern trans-European ideal (which is moot), it is not language which unified but religion. With the disintegration of that metaphysical division, one can only hope that European unification will indeed bring peace and prosperitiy -- but religion can play absolutely no role in that process or success will turn into an ignius fatuus and waft away. Europe needs an objective even to survive. I might try unifying peace and prosperity by which means it may bury a VERY sordid past yesterday, and bury it in the past. A little isolationism is good for meditation, and contemplation of the future is a better bet than monumentalizing the past. That is particularly true of Europe, where the reminders keep creeping in between now and the future.

When Frederick II came to the throne in 1215, he tried to extend the HRE even more towards Italy (his father married the heiress of the throne of Sicily). His main ambition to create such an empire was because of the constant clashes with the papacy. His vain efforts to gain strength in Italy only weakened him in Germany, leaving the German dukes and princes free to govern Germany.

After the death of Frederick II, the HRE rapidly declined. The German monarchs continued to be called HRE emperors, but they held little power.

The Holy Roman Empire was never a real "country," but rather a motley confederation of mostly independent (mostly German-speaking) states. During the Middle Ages, it did, however, prove itself capable of rallying behind an elected Emperor for crusading or other religious purposes.

In contrast to other answerers above, I date the (de facto, not de jure) collapse of the Holy Roman Empire to the Thirty Years War, 1618-1648, between the Swedish-led (Protestant) north German states, and the Austrian-led (Catholic) south German states. By splitting the "empire" into Protestant and Catholic camps, the long war destroyed the common ethos that had hitherto bound the different states, and made the "confederation" a shell of disunited, often warring entities.

The Holy Roman Empire was a bit more unified during even its latest phase than many answers have said.

After the thirty ears war many German sates rallied to support he Emperor in the period calling the Imperial reaction which lasted until the 1720s when Emperor Charles VI had to curry favor with the various states to get their support for his daughter's succession.

By 1720 Charles VI had become about as powerful in Germany as Ferdinand II had been at is peak in the Thirty Years War, but without fighting any battles. But then he had to negotiate support for the Pragmatic sanction with the princes treating them as his equals.

If either Joseph I or Charles VI had had a son who grew to adulthood the imperial Reaction may have continued much longer and the war of The Austrian Succession might not have happened and the rivalry between Prussia and Austria might not have happened.

Also during the War of the Spanish succession Emperor Joseph I was able to confiscate several small states in the Kingdom of Italy or Lombardy, and in one particular year he actually manged to collect more Imperial War Tax from the Kingdom of Lombardy than from the Kingdom of Germany, so Italy was not yet totally outside of the Empire.

The Holy Roman Empire (of the German Nation) officially ceased to exist one fine day in August of 1806 when Francis II went to the Imperial Diet and resigned. He of course continued to be the Emperor of Austria-Hungary, but that is another story.

What only a small number of people thought about was the fact that for the first time since 31 BC,there was not a single political institution called "Roman Empire". In that year, when Octavian had fought the Battle of Actium and established himself as Princeps (First Person) in a situation that was widely regarded as an imperial arrangement, there had been a Roman Empire of some sort. Whether as a Principate, a Dominate, an Eastern and a Western Empire, an Empire in the East that called itself "Romaioi" (Greek for "Romans"), or as a Germanic Empire that called itself "Holy Roman", there had ALWAYS been a Roman Empire! And yet, as TS Eliot would later say of the world, it died, "not with a bang, but a whimper".

Why did it die? Well, it failed to make a Nation-State out of Germany. It failed to ever have a stable method of succession to the throne. And the Emperors had a hard time justifying their right to rule, given the first two limitations.

Of course, the immediate cause of death listed by the Coroner was the Battle of Austerlitz and the creation of the Confederation of the Rhine. But the above three reasons had rendered the Empire impotent for years.

As I stated in my answer on Frederick II, the book will be out in a few years and then you will know WHY those three things above happened as they did. But for now, those reasons are sufficient, as explaining why the reasons obtained will be a book-length answer.

To build on GPierce's answer, the HRE functionally collapsed much before that time. The Thirty Years War (1618-1648) had really taken a toll on the HRE's central government. It left the country politically and religiously divided, which was a major issue to unification at that point in time. The country was ruled by princes who controlled city states that were loosely connected. This remained until Napoleon, as Gpirece stated, swept across modern day Germany.

Officially it collapsed after falling to Napoleon with the 4th treaty of Pressburg, but had been fading for some time before that. The empire was pretty decentrized in nature, but various events such as the Peace of Westphalia after the thirty years war, which granted dominions effectively independence in all but name. Nations, especially the Hapsburgs in Austria, looking to consolidate their own domains over that of the empires, and the thwarting of policies that would have brought more centralization to the empire's rule.