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This depends a lot on the countries involved and the specific airlines.
In most parts of the worlds (EU, US), you are entitled to a full cash refund if the airline cancels the flight. Some airlines will still refuse and will try to offer you flight vouchers or free re-booking instead. If that's the case you will have to be persistent in demanding a cash refund.
In other countries (Malaysia for example) there is no requirement for a cash refund. So you really need to check your specific case especially if it involves multiple countries.