Which battle was the most lopsided result in terms of casualties?

To add to the other answers, I want to mention the Battle of Tsushima.

The Russian losses were 4,380 dead and 5,917 captured, i.e. 10,297 in total.

Japan's losses were 117 dead.

The ratio is 1:88.

Another pretty one-sided battle was the battle of Casilinum in southwestern Italy in 554 AD, between roughly 20000 East Romans under Narses and similarly many Franks under Butilinus. According to Agathias (who is probably exaggerating a lot) the Romans lost 80 men and the Franks lost all except 5 men. This although one part of the East Roman had initially declined to fight and only arrived on the battlefield after the Franks had started their initial charge.

Another colonial battle: Battle of Namutoni (1904) in German South West Africa (today's Namibia):

Four German colonial soldiers (Schutztruppe) and three German reservists defended the Fort Namutoni with 1500 rounds of ammunition against about 500 Ovambo warriors. The Germans held out all day and retreated during the night without casualties, the attacking Ovambo had 68 killed, 48 missing and 20 wounded.

The abandoned Fort Namutoni was destroyed during the following days and rebuilt two years later. Today it is one of the campsites in the Etosha national park.

Caernarfon Castle was defended by a force of 30 (I found a number of references that state 28) against an attacking force of both the Welsh and French with siege engines and battering rams. (1403) It's even mentioned on the netflix series "Secrets of Great British Castles".

I don't think it's known exactly the size of the attacking force; However the book "Castles, Battles, and Bombs: How Economics Explains Military History" states that they were able to inflict 300 casualties. This gives the very worst ratio of 1:10 ... but a potential best of 0:300.

There is also the battle of Agincourt https://en.wikipedia.org/wiki/Battle_of_Agincourt

• 112-600 killed vs 6000 killed + 700-2000 captured giving it the low end of 1:11 to the high end of 1:71.

I would also suggest your definition of "significant" being 10k men is a little wonky - in that battlefields have changed significantly with time - a Roman legion was 6k men - most battles would be unlikely to involve more. This doesn't make the battles any less significant...

The Battle of Blood River easily wins this award.

Casualties were: 3 wounded, 0 deaths vs. 3000+ dead, i.e. a casualties ratio of infinity.

Salsu River in 612 is a strong contender, made all the more notable by the victor's forces having been massively outnumbered.

In the course of the Second Goguryeo-Sui War, a 300,000-or-so-strong Sui army attacked approximately 10,000 Goguryeo cavalry at the Salsu River and were almost completely destroyed, with only 2,700 (less than 1% of the original force) escaping with their lives; the massive losses suffered in the battle would prove to be one of the factors leading to the collapse of the Sui dynasty. Casualties on the Goguryeo side were unknown but presumably light, given that they decisively won the battle.

Due to the lack of information concerning Goguryeo casualties suffered in the battle, an exact kill:loss ratio cannot be calculated; however, given the number of soldiers they started out with and the losses they inflicted on the Sui army, it would be mathematically impossible for their kill:loss ratio to be any less than ~29.7:1 even if they were completely wiped out, and, since they decisively won, and their casualties can, thus, be presumed to have been fairly light, the actual kill:loss ratio must have been, correspondingly, even greater (potentially much more so - for instance, if there were actually 2,500 Goguryeo casualties, the true kill:loss ratio would be 118.9:1).

There is a historical record of the battle with 50 thousand to 0 score.

According to Procopius, during the war with Vandals, there was a battle near the Bourgaon (Libya) in which the Roman general Solomon defeated the army of Moors.

And there perished in this struggle, among the Moors fifty thousand, as was declared by those of them who survived, but among the Romans, no one at all, nor indeed did anyone receive even a wound, either at the hand of the enemy or by any accident happening to him, but they all enjoyed this victory unscathed.

Cited from Procopius, Loeb Classics edition, vol 2, Book IV (the Vandalic war-2), xii, 25-26. (Greek with parallel English transl., available online).

Procopius was a secretary of the Roman Commander-in-chief Belisarius, and he was participating in the events he described. He is generally trusted by modern historians. (You can even see from the cite above how carefully he states the facts:-)

The Battle of Omdurman, 2 September 1898, between British and Egyptian forces under Lord Kitchener avenging the death of Chinese Gordon against Sudanese forces led by bdullah al-Taashi.

Despite being outnumbered by about 2:1 (26,800 vs ~52,000) the British inflicted an estimated 12,000 killed on the Sudanese forces for just 48 (or perhaps 47) killed, a ratio of ~250:1. Counting wounded and prisoners the totals are 30,000 vs 382, still a respectable ratio of over 76:1. As Kipling famously noted:

Whatever happens, we have got
The Gatling gun,; and they have not.

Wikipedia:Battle_of_Cajamarca, assuming that contemporary accounts were accurate.

Conquistador Francisco Pizarro ambushed the Emperor Atahualpa. The Spanish suffered no deaths and one wounded. The Incans suffered 2000 dead with 5000 more taken prisoner.

The Battle of Agincourt (1415)

French strength:       12,000 - 36,000 (modern estimates)
English strength:       6,000 -  9,000

French casualties:     approx. 6000 killed
English casualties:    112 - 600 killed

Strength ratio (F:E):  min 4:3,  max 6:1
Casualty ratio (F:E):  min 10:1, max 53:1

Numbers above from Wikipedia entry

History.com entry which validates English strength number (actually says the English strength would be half of 11,000) and the French casualty estimates.

New York Times article reporting on recent research which numbers the English at between roughly 6000 and 8600 by the time of the battle, and the French at somewhere between 12,000 and 24,000.

The battle of Aquae Sextiae (102BC)

As with all ancient battles there is a wide variety of figures thrown out for the casualties and participants for this battle.

Roman Total Forces = 40-50k (6 Legions plus auxiliaries) & Roman Casualties = 500-1000

Teutones/Ambrones Total Force = 50k - 150k & Tuetones/Ambrones Casualties = 30k - 120k

upper end ratio would be around 300:1 (150k/.5k) and lower end would be 30:1 (30k / 1k)

I would imagine the truth is somewhere in the middle of those ranges.

After doing some more research I found out about 2 naval battles in WW2, the Hi-81 convoy battle and the battle of the Bismark Sea. I do think these would count using the OPs qualifications as both had over 10k participants.

Battle of Bismark Sea - 2–4 March 1943

The Battle of the Bismarck Sea (2–4 March 1943) took place in the South West Pacific Area (SWPA) during World War II when aircraft of the U.S. Fifth Air Force and the Royal Australian Air Force (RAAF) attacked a Japanese convoy carrying troops to Lae, New Guinea. Most of the Japanese task force was destroyed, and Japanese troop losses were heavy...

...The battle was a disaster for the Japanese. Out of 6,900 troops who were badly needed in New Guinea, only about 1,200 made it to Lae. Another 2,700 were saved by destroyers and submarines and returned to Rabaul.[63] About 2,890 Japanese soldiers and sailors were killed. The Allies lost 13 aircrew, 10 of whom were lost in combat while three others died in an accident. There were also eight wounded. Aircraft losses were one B-17 and three P-38s in combat, and one B-25 and one Beaufighter in accidents. MacArthur issued a communiqué on 7 March stating that 22 ships, including twelve transports, three cruisers and seven destroyers, had been sunk along with 12,792 troops

Allied deaths = 13

Japanese Empire deaths = 2390

Ratio = 222:1

Convoy Hi-81 - November 15–18, 1944

Convoy Hi-81 (ヒ-81) was the designation for a formation of Japanese transports that carried soldiers bound for Singapore and the Philippines during World War II. The transports were escorted by a large force of surface combatants including the escort carriers Shinyo and Akitsu Maru which were sunk in the Yellow Sea by American submarines. Over the course of a four-day convoy battle in November 1944 nearly 7,000 Japanese were killed in action while the Americans sustained no casualties.

Ratio = infinite

addendum:

Additionally there was the battle of hi-71 which was another convoy battle which occured from August 18–19, 1944. This battle resulted in 60 killed for the Allies and 8k killed for the Japanese Empire. Resulting ratio is:

133:1

#2 (07242020) I was reading about the Italian-British naval actions during WW2 and I came across the Battle of Cape Matapan It had over 10,000 participants and the result was 3 dead on the British side and 2,300 on the Italian side giving a ratio of around

766:1

Tsushima 1905. 117 vs 4380 dead. Fleet engagement, so the Japanese + Russian numbers of men, combined, probably were over your 10k threshold, but that 4380 looks like it was most of Russian fleet.

The Invicible Armada lost 15000 men in 1588, but most of that was also due to weather on the retreat trip around Scotland. English losses were about 400. The wikipedia entry is unclear about the ratio as it tallies up English losses due to disease the following year. But the overall picture of the initial battle + retreat is one of the most lopsided victories in history.

Wikipedia:SpanishArmada and ThisDayInHistory:SpanishArmadaDefeated

Some of the early battles of Barbarossa, say July-Oct 1941, consistently had some really lopsided numbers as well, when you tally up the POWs in the encirclement phases, but nowhere as extreme as some other battles others will cite. Yet, this happened at such a scale that it merits mention as well, even if the ratios aren't as high.

Kiev - Aug 1941

German: 100K casualties (from which 95K are wounded). USSR: 615 KIA+POW (plus 85K wounded)

The reason I am breaking out wounded here is that you can have a reasonable expectation that some/most of the wounded will be back on the front in some capacity later on. Not so with a KIA or POW.

(the same logic applies to tank battles, whenever you read loss ratios - whichever side occupies the territory after a battle can salvage some of their tanks, but the side that withdraws loses any immobilized tank).

If you assume 50% can heal and fight again, German losses are about 50K vs 650K+ Soviet side. So, from 1-7 to 1-13

I admit, this is a bit of a cheat in the context of this question, but its effect was certainly true in practice and it worked the other way too - the 300K POWs at Stalingrad were a full loss to the Nazis. Tactically - irrelevant, strategically - quite relevant.

Suomussalmi, Russia-Finland Winter War 1939

• Finnish 1750 casualties from 11500 troops.
• Russia 15000-25000 from 45-55K troops.

All the more impressive since the artillery, aviation and tank advantage was massively Russia's.

Last, but not least, how could we forget everyone's favorite Hannibal?

Cannae 216 BC

5700 Carthagians KIA, 67-85K Roman KIA

Lake Trasimene 217 BC

1500-2500 KIA Carthage vs 15K KIA + 15K POW Rome

1988 - Battle of Afabet

Fought between an Eritrean People's Liberation Front (EPLF) force of around 15,000 and an Ethiopian army numbering 20 to 25,000, this was a huge defeat for the latter.

Ethiopian casualties were over 18,000 killed or captured while EPLF casualties amounted to only 394 (125 killed, 269 wounded, giving a ratio of at least 45 to 1.

1798 - Battle of the Pyramids

On the 21st of July 1798, Napoleon's army scored a decisive victory over a Mamluk army. Although the total size of the armies is disputed, the French numbered at least 20,000 while the Mamluk estimates range from 12,500 to 40,000.

French killed amounted to just 29. Estimates for Mamluk killed on French Wikipedia range from 1,200 to 8,000. The ratio of Mamluk killed to French killed was therefore at least 41 to 1 Total French casualties (killed and wounded) were 289 while, accordion to Napoleon himself, Mamluk casualties amounted to 20,000 (mostly likely a very generous guess), giving a ratio of 69 to 1.

1504 - Battle of Cochin

Fought between Portugal and their Cochin allies against Calicut and lasting from March to July, this was actually "a series of confrontations" but is worth a mention as there were no reported fatalities on among the Portuguese and 'neglible' among the Cochin while their Calicut opponents lost 5,000 killed in action and a further 13,000 to disease.

260 AD - Battle of Edessa

A Roman disaster to rank alongside Carrhae mentioned in JLK's answer. Roman losses were at least 60,000 (with Valerian having the dubious honour of being the first Roman emperor to be captured). Sassanian casualties were "minimal".

422 BC - Battle of Amphipolis

Fought between the Athenians and the Spartans in 422 BC during the Peloponnesian War, this was a comprehensive Spartan victory and the killed ratio reflected this: about 600 Athenians to just 8 Spartans, a ratio of about 75 to 1.

This battle was also notable for those involved and for the fact that the commanders of both sides died: the Athenian general Cleon and the Spartan Brasidas (who lived long enough to see the victory). Brasidas was the outstanding military officer of the first part of the Peloponnesian War; an ossuary believed to contain Brasidas' remains is on display at the Archaeological Museum of Amphipolis.

Amphipolis also saw the end of the historian Thucydides' military career, while the philosopher Socrates was among the Athenian survivors (according to Plato's dialogue, Apology)).

Battle of Gaugamela in 331 BC between Alexander and Darius III's Persians.

One of Alexande's great victories. Even if we take the highest estimate for Alexander's casualties (1,500) and the lowest for Darius III's army (40,000), it still gives a ratio of 26.67 to 1.

Battle of Carrhae in 53 BC between the Romans and the Parthians.

This is the famous battle where Crassus came to a sticky end. The Romans suffered about 20,000 killed (according to Wikipedia) or 24,000 killed (according to Ground Warfare: An International Encyclopedia, Volume 1). The Parthian casualties were minimal (according to Wiki). Actually, Wiki gives 38 but even if we consider 1,000, the ratio is 20 or 24 to 1 killed.

Pearl Harbor attack:
Discarding the materiel lost, the USA had 2,335 killed and 1,143 wounded, while Japan had only 64 killed and 1 prisoner. That makes a ratio of 1:56.
If one adds in the materiel probably the difference is quite bigger.

Battle of Sidi Barrani:
During operation Compass, the British had 624 losses, while Italy had 2,194 killed, 2,286 wounded and 38,300 prisoners. That makes a ratio of 1:69.

Many naval battles might fulfill the request, because it is easier to understand that one side has many losses, while the other none. For example, the sinking of the battleship Bismark (5 losses for UK and 2,310 losses for Germany), or the [battle of Cape Matapan].5 (3 killed for UK and 3,315 losses for Italy, ratio 1:1100!)