What was Pizarro's route between Spain and Peru?

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The original route was across the isthmus from Nombre de Dios to Panama City. Later, the city of Portobelo, which is near to Nombre de Dios, became the Caribbean hub for the south seas. The road between Portobelo and Panama City was called Camino Real. The South Sea fleet of the Spanish crown operated between Panama City and two ports in Peru: Arica and Callao. To get the fleet to Panama City it had to be sailed through the Straits of Magellan, a dangerous journey. Panama City had been founded by Pedro Aria Davila in 1519 a few years after Balboa had made the first expedition in 1513 to the South Sea, which later became known as the Pacific Ocean. Francisco Pizarro had been a soldier in Balboa's expedition and used the newly founded Panama City as a base for his conquest of Peru. The routes of his main expeditions are as follows:

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