score:59
John Hanc**k was the President of Congress. So, as stated, he signed first and largest. In the leftmost block are the signers from Georgia. In the block immediately to the right of that one are the signers from North Carolina. The block below contains the signers from South Carolina. This pattern continues throughout with a few exceptions. Here is a visualization:
Two exceptions: John Hanc**k, although from Massachusetts, did not sign with the rest of the Massachusites as he was the President of Congress. Also, Matthew Thornton did not sign with the rest of the New Hampshirites.
"Because of a lack of space, Thornton was unable to sign next to the other New Hampshire delegates; he instead placed his signature at the end of the document, on the lower right." -Wikipedia
The blocks are also categorized. Start at the leftmost column and go to the rightmost column. Begin with the bottom of each list: Georgia, South Carolina, North Carolina, Virginia, Maryland, Delaware, Pennsylvania, New Jersey, New York, Connecticut, Rhode Island, Massachusetts, and New Hampshire (we skip Matthew Thornton's Signature here). This is roughly the order of the colonies, going South to North along the Atlantic Coast.
So, to sum it up, for the most part, the signers signed with the rest of the signers from their respective state.