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There are a lot of questions in 1 but let's go in order:
Your port of entry to the US doesn't have to be San Francisco if your visa is granted. You can enter at any border crossing.
As long as your visa is valid you should be able to enter the US. See: Travelling to the US on B1 visa without a business purpose for more information.
Your wife's visa is a separate concern altogether and should be addressed as such. Your tourist (B1 or B1/B2) visa doesn't entitle your to bring anyone other than yourself to the US, so her visit will probably be addressed separately from yours.
Depending on the visa validity period you should be able to travel at any point during that validity period. I am sure there was a question here about it but I can't find it at the moment.