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Of course there are many specific occurrences of the Spirit speaking in the Bible. All prophecy and scripture is the Spirit speaking. Thus says the Lord, is the same as thus says the Spirit.
And coming to us, he took Paul’s belt and bound his own feet and hands and said, “Thus says the Holy Spirit, ‘This is how the Jews at Jerusalem will bind the man who owns this belt and deliver him into the hands of the Gentiles.’ ” (Acts 21:11, ESV)
He who has an ear, let him hear what the Spirit says to the churches. (Rev 2:2, ESV)
Therefore, as the Holy Spirit says, “Today, if you hear his voice (Heb 3:7)
And many other similar references could be tallied.
With regard to the specific verse you mention, the Spirit is to ‘explicitly say’ this seems to imply more then the general inspiration of scripture but particular prophecies that speak directly to a specific situation, i.e. a horrible apostasy from the gospel in the ‘last times’.
Jamieson-Fausset-Brown Bible Commentary, conveniently identifies a few verses, the Spirit has spoken about on this particular subject.
the Spirit-speaking by the prophets in the Church (whose prophecies rested on those of the Old Testament, Da 7:25; 8:23, &c.; 11:30, as also on those of Jesus in the New Testament, Mt 24:11-24), and also by Paul himself, 2Th 2:3 (with whom accord 2Pe 3:3; 1Jo 2:18; Jude 18).
expressly-"in plain words." This shows that he refers to prophecies of the Spirit then lying before him.
The Apostles all seemed to have a clear vision of this ‘future event’ as it shows up in various locations in the Bible. ‘The Spirit speaking explicitly’ the apostle understands not a revelation made to him alone, but that the infallible Spirit of God and the Spirit of prophecy guided he and the rest of the apostles to instruct the church and prepare it for this specific future danger. This Spirit of prophecy is the Spirit speaking.
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Generally, no spirit has any physical form ( either holy or evil), which means we can't see spirits with our naked eyes. And for both the good and the evil spirits to speak, physical beings have to be possessed by them. Besides, The Holy Spirit is the Spirit of God. When God speaks, the Holy Spirit speaks and when the Holy Spirit speaks, God speaks. Remember this however that it was only Jesus who saw the dove descending, the heaven opening, and the voice saying "This is my beloved son..." It was not specifically confirmed whose voice it was. Maybe the same Holy Spirit that was descending in form of a Dove was also the One speaking from heaven, no one knows.
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Hebrews 10:15, 16, 18
The Holy Spirit also testifies to us about this. First he says:
"This is the covenant I will make with them after that time, says the Lord. I will put my laws in their hearts, and I will write them on their minds.”
Then he adds: “Their sins and lawless acts I will remember no more.” And where these have been forgiven, sacrifice for sin is no longer necessary.
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Greek text of Stephanus 1550:
τοῦ δὲ Πέτρου ἐνθυμουμένου περὶ τοῦ ὁράματος εἶπεν αὐτῷ τὸ πνεῦμα Ἰδού, ἄνδρες τρεῖς ζητοῦσιν σε
English translation:
While Peter thought about the vision, the Spirit said to him, "Behold, three men seek you."
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the Holy Spirit said, "Set apart for me Barnabas and Saul for the work to which I have called them." (Acts 13:2)