According to Creationists, what are the strongest arguments against abiogenesis?

I'll offer 3 critiques

1. A leap of faith too far

For purposes of this post I'll use as a working definition of faith the one proposed by @curiousdannii - reliance on something because of its past behavior (the popular refrain that faith is belief without evidence is a strawman--see further discussion in my post here).

All life forms with which we have experience result from one or more previously-existing life forms; we do not have evidence of life (much less self-replicating life) emerging from non-life by natural processes alone.

All of examples of specified complexity with which we have experience are the product of intelligent minds; we do not have evidence of specified complexity emerging from natural processes.

This does not mean these things cannot happen - it means we don't have evidence to support that they happen. To accept a priori that methodological naturalism provides the best avenue for answering the question of the origin of life is to decide on the very variable under consideration before even looking at the evidence (not very scientific!).

Trusting in methodological naturalism to deliver results in the study of origin of life is an act of faith.

• The scientific method, as well as theological systems that accept the ongoing nature of revelation, have built in systems to allow for correction when errors are made.
• Naturalism is a binary philosophical assumption that can either be accepted or rejected. It cannot correct itself - the most it could ever do is fail enough times that people choose to discard it.

I can see why people would put faith in the first two; it is unclear to me why anyone would put so much faith in the latter.

Those who suspend judgement on the matter of the origin of life may be intellectually consistent, but those who actively believe that naturalism will eventually produce a solution to the origin of life problem are making a god-of-the-gaps argument: I can't yet answer this question, therefore I assume naturalism will eventually produce an answer. This is a faith-based position, relying upon prior results from methodological naturalism (whatever those might be) in order to trust it.

This is why Frank Turek is famous for his claim I don't have enough faith to be an Atheist.

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2. Probability

Doug Axe famously argued that the sequence space for protein folds is too vast for successful innovation by chance, indicating that only approx. 1 in 10^78 possible DNA variations is viable.

Since there have been (generously) 10^42 life forms in the history of earth, we would have to replay the entire history of life on earth about 1,000,000,000,000,000,000,000,000,000,000,000,000 times in order to get just one new protein fold to come into being by chance. Adding in the need for multiple protein folds, to say nothing of a self-replicating mechanism, would make the chance-hypothesis even weaker. This objection is relevant to both origin-of-life and evolution-of-life studies. For abiogenesis to work, we would need multiple successful protein folds, and a self-replicating mechanism.

If we grant that there are 10^23 habitable planets in the universe, and the earth represents an "average" habitable planet, even then, the entire universe would not give us 10^78 opportunities for an accidental life form to emerge and replicate itself even once. (10^23 * 10^42 = 10^65).

Facing otherwise insurmountable odds, some philosophers have turned to multiverse hypotheses. While I take no issue with the possibility that more than one universe could exist, this is not a scientific theory, it's a philosophical theory (it's non-falsifiable), and it is vulnerable to the same difficulties discussed in section 1 of this post.

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3. Occam's Razor

Upon re-reading the original question, I see that my response left out a significant dimension: this question is addressed to Christians, who already believe in God.

To those who already believe in God on other grounds, abiogenesis is an unnecessary and redundant hypothesis. Abiogenesis (at least as it is usually presented) is an argument that is designed (see what I did there?⁼⁾) to explain the accidental origin of life. Those who believe in a Divine Creator on the basis of sacred texts, the witness of the Holy Spirit, objective moral truths, etc., conclude that life is not an accident. Abiogenesis requires believing in the fantastically improbable in an effort to avoid believing in a Creator (no but really--consider multiverse models that are willing to accept--no matter how unlikely--the reality of every scenario imaginable except one in which God exists). Those not pre-committed to such naturalistic conclusions could amusingly reverse Laplace's own statement to argue against him: when it comes to abiogenesis, I have no need of that hypothesis.

The first two sections of my argument show why abiogenesis is a weak hypothesis, and ought to be treated skeptically on probabilistic grounds. The third section of my argument acknowledges that a belief in God can be (and usually is) reached through independent means. To those who accept the teaching of Genesis that God created the heavens & the earth (see Genesis 1:1), theories on the accidental origin of life fail the Occam's razor test--they multiply hypotheses beyond necessity.

For my own part, I came to a belief in God for reasons unrelated to the structure of cells. A study of biology reinforces that belief on teleological grounds, and perhaps more importantly, increases my respect for the Creator.

Conclusion

Given the available evidence, an intelligent mind appears to be the most viable explanation for the existence of specified complexity in life - it is the only theory that can point to real-world examples where the proposed source has actually produced the effect in question.

I also take no issue with the possibility that the Creator could use natural processes (like a programmer uses the natural properties of silicon) to carry out His intentions. This wouldn't make the Creator any less powerful--it would just mean He's smart. I lose no respect whatsoever for the Wright Brothers by discovering how they did their work.

I see no conflict between respect for the Creator and an awareness of how He performed some small portion of the creation.

Appendix

The teleological argument from biological specified complexity is an argument for an intelligent mind behind creation, not an argument for many of the specific theological claims about God. Teleology is often used to establish that there is a Creator; understanding the nature & intentions of the Creator is the business of theology.

(teleological arguments--from the Greek telos, meaning "end" or "goal", use features of the universe that show evidence of being designed to argue for the existence of a designer)

Response to objections

The probability section seems to ignore (a) the possibility that DNA started off simpler

My calculations required only 1 protein fold...hard to ask DNA to deliver a result much simpler than that.

(b) that natural selection guides the randomness

This would be a novel theory of evolution, and is not consistent with the modern synthesis of Darwinism, which holds that natural selection acts upon random mutation. Random mutation is just that, it's random. Natural selection merely favors/disfavors from what it is given to work with. It cannot guide which mutations occur, only which mutations survive.

(c) that all mutations may not be equally likely or even possible

Axe's work focused on viable combinations vs. possible combinations.

(d) mutations of viable variations are much more likely to be viable variations themselves

While this may be true, it would be stronger if defended with evidence. In any event, this would be applicable to the evolution of existing life; it has nothing to do with abiogenesis.

Evolution cannot start until there exists a chemical structure which can replicate itself. And this supposed replicating structure must be in some sense a step towards the DNA structures that all life is made up of today. (So it is, for instance, quite useless to theorise early evolution starting by making use of the self-replicating features of certain crystals.)

Evolutionary processes may be described as the incorporation of changes to a self-replicating compound which are beneficial to the compound and so are passed on to the next generation. But before the evolutionary process can begin all the features of self-replication must be produced in the same compound without any assistance from the process of natural selection. And so the more complex the original compound needs to be the more unlikely it can possibly come into existence by chance.

Life is made up of amino acids. But amino acids cannot self-replicate. Proteins are specific chains of amino acids. But proteins cannot self-replicate.

The only thing which can self-replicate are DNA chains, which are chains of chemicals which are the information needed to produce proteins. Once a protein chain has been built it needs to be folded correctly in order to work. But this folding is done by structures made up of correctly folded proteins, a catch 22 situation.

The number of possible combinations of amino acids producing a chain of 150 in a single protein is mind-boggling. There are said to be between 10 to the power 78 and 10 to the power 82 atoms in the visible universe. The average protein length in today's world is, say, 150 amino acids. And there are say 20 amino acids used in living things. That means that there are 20 to the power of 150 different possible permutations of amino acids for such a protein length. And the simplest living things known to exist contain over a 100 different kinds of protein.

But the problem is bigger than this, because even though there are only 20 (or 21 or 22?) different amino acids used to make all life forms there are in fact over 100 different kinds of amino acids in nature: these make possible (at least) 100 to the power of 150 (which is the same as 10 to the power of 300) different protein chain combinations. Compare this with 10 to the power of 82, the upward estimate of the number of atoms in the visible universe.

The whole thing is riddled with impossibility upon impossibility. I would say it is amazing that even God has made living things out of just matter. Or has he? The body goes back to the dust of the earth and the spirit goes back to God who gave it (Ecclesiastes 12:7).

If you still need to be convinced then see Professor James Tour from Rice University's interview here:-

Youtube - "James Tour: The Origin of Life Has Not Been Explained - Science Uprising Expert Interview" https://www.youtube.com/watch?v=r4sP1E1Jd_Y