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The Obadiah passage is a prophecy against the Idumeans (the Edomites), who were displaced from their kingdom by the Babylonians and took refuge in rocky crags, settled in southern Judah, but were eventually completely destroyed. This is because they watched as Israel suffered this fate before them, and they gloated, offered no help, and even joined in the plunder of Israel.
Most prophecies use imagery that says one thing but means another. Here making a nest among the stars refers to the nature of their new home and their eventual fate.
A second application of this verse to space travel is unwarranted, though if pride like that of the Edomites attends such an ambitious project, the result might be the same.
For references, consult Wikipedia or this commentary resource:
https://www.preceptaustin.org/obadiah_commentaries
However, if I were to have reservations about space travel, it would be because of the Tower of Babel. The heart atitude of the builders was the problem, not the fact that they were building a skyscraper.
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An intriguing question. But I’ll take a stab at it. There is no direct command not to explore space. As noted in the other comment the scripture in Obadiah is a pictorial prophecy aimed at the Edomites.
However Psalms 115:16 states...
“ As for the heavens, they belong to Jehovah, But the earth he has given to the sons of men.”
Also, considering how inhospitable space is for humans, and how much effort our creator put into making the earth wonderful for us (as recorded in Genesis) it seems reasonable we were meant to stay put.