score:7
Years ago, I took the long distance bus from Washington DC to Niagra Falls. While the majority of the journey was at night, the last few hours were in daylight. To be honest there was little to see or do. There was no commentary from the driver, just brief announcements of the next stop coming up. After all, this was not a tourist bus, but just a cheap way of getting from A to B.
There were the scheduled stops at a few major cities: The bus would leave the Interstate, trundle through the city streets to the bus station, and then trundle back to the interstate. We saw a lot of bus stations, but nothing of the cities attractions unless the bus happened to pass by them.
We made one other stop at some anonymous truckstop for about 30 minutes in the middle of the night. I think this was to refuel the bus. It was cold and dark and I just drank lots of coffee.
Even the daylight portions through upstate New York were boring as hell. Endless miles of Interstate and flat fields, was all there seemed to be to look at.
Since then, I've done several vacations in the USA where I have rented a car and had a great time on the road.
In short: if you want to see the sights on the way, you would be better off driving, and perhaps taking a few days to do it.