Upvote:2
No, because of a structural issue. PC cases are not made for the dynamic forces they would encounter being rolled around. It would twist and crack the PC case to the point of falling apart. Honestly, CostCo-tier luggage can barely handle it, and it's made to be luggage!
Besides, even if you were exceptionally careful the vibration (rollers) and shock (bumps) would still unseat boards and connections. Every card slot would at risk of popping out. I've had that happen simply from customers bringing their PC into the service department, that's why when someone rents 40 PCs I sent 43. Reseating boards is one of the first things you do when opening up a case on the service bench. I could also see heat sinks being torn off, CPUs unseated, and other adventures. *Those clips are simply not made for these dynamic forces. Look at aviation grade computers for instance - very different.
I actually do have a "travel with desktop PC" requirement, so I've given it a lot of thought. For a PC to endure such treatment, I'd want an all-soldered PC - video card part of the motherboard and soldered down, SSD drive (certainly not HD) also soldered, and RAM either soldered or with really good clips. At that point we're talking about a PC that is a single board; it'd be so small you'd wrap it in a couple sweaters and toss it in your carry-on.
The Mac Mini comes to mind.