Follow all safety procedures and be extra careful. Wear mask at all times, stay away from other people as much as possible, pick a seat in empty row (if possible), wash hands frequently, etc.
Check Covid testing and quarantine requirements for the US state, county and city that
you will be staying in.
If you need to stay in quarantine for an extended time, arrange for it: Make sure you have a safe & well isolated place to stay, figure out how to get food & supplies, have a safe means of communications and ideally some local contacts.