score:3
Question #1: Where in Detroit? - city center or suburbs? This is important!(I'm a born and bred Detoit area person.)
Detroit proper or southern/southwest suburbs - I-75 or maybe I-75 and US 23 depending on where.
Northern suburbs - Take I-75 to US 23 near Toledo. This will avoid a lot of traffic (and I believe there also heavy construction on I-75 south of Detroit) and then east on I-94 or I-96/696 depending on where you're heading.
Both 75 and 65 are flat and boring so I'd go for shorter in this case. There is a MIDrive app for your phone for specific construction info.