Upvote:2
You will need to apply for a single Schengen visa for 2 or multiple entries, covering the entire trip USA-Italy-India-Netherlands-USA.
Since Italy is your main destination (in this case, the Schengen country you will be staying the most days in), you must apply to the Italian consulate, but with itinerary and other documentation that covers your entire trip. The visa they issue should be valid for both parts of the trip.