Upvote:0
The CBP doesn't have immediate access to what you wrote in the DS-160, because it's not relevant. A visa was issued, and all you need to do is fill out the blue form correctly (putting the new address on it) and answer the officer's questions truthfully.
Like Michael Hampton wrote, as long as your planned activities remain consistent with your visa, you'll be fine if otherwise deemed admissible by the officer you get.
Upvote:4
Changing your hotel accommodations is no problem.
You only need to write the street address of your new accommodations on your landing card, which you will fill out on the plane and give to US immigration and customs officers. Make sure that you have the correct street address before you depart. (You'll also need it to give to your taxi driver.)