Driving a rental car from east to west coast of the USA as a visitor
score:10
Accepted answer
Yes, you can. However,
make sure that you booked your rental car in advance for a price that includes the one-way fee for this route (these fees can be very high). Also make sure that the quoted rate is for a non-resident, includes a reasonable insurance and is valid for drivers from your country (US citizens get different rates).
look up the differences in traffic rules of all US states that you are passing through
check whether your national driver's license is enough for the states that you are passing through. Different states have different rules and you may need an international driver's license in addition to the one from your home country. An example is the state of Georgia, where foreign licenses that have not been issued in English language need an additional international one.
As tricasse wrote, you will need a credit card and of course a valid driver's license from your home country.
As Yehuda_NYC added, you may want to check if you meet the minimum age requirement imposed by the rental car company.