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Alexander died in June, 323 BC. By accounts.... 1: Plutach says 2 weeks before his death; he entertained an Admiral and Medius, to which he developed a fever. Was unable to speak. 2: Historian Diodorus argues Alex was struck with pain after drinking huge bowl of unmixed wine and died of stomach pain. Drinking undiluted wine, worse wine spoiled can be exceptionally bad.
More scenarios suggest foul play, given lengthy history of aristocracy propensity for assassination in Macedonian culture......suggest he may have been poisoned.
1998 New England Journal of Medicine suggested he died of Typhoid, disease common in Babylon where he last was resided. another is Sepsis from bowel perforation (obsessive alcohol consumption and stress).
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According to the University of Maryland School of Medicine report of 1998, Alexander probably died of typhoid fever (which, along with malaria, was common in ancient Babylon). Wikipedia