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Did he literally bleed through his pores as could be interpreted from this verse?
Yes. This condition is called Hematidrosis.
What would cause him to sweat blood during a prayer to his Father?
Hematidrosis may occur when a person is suffering extreme levels of stress; for example, facing his or her own death.
What is the spiritual meaning behind this sweat of blood that came from his body in the Garden of Gethsemane?
Was he feeling pain that required an angel to strengthen him in order to bear what he was feeling?
I would not call it pain, I would say intense spiritual agony. Being the Son of God, he knew in detail everything that was about to happen to him. He knew that he was facing physically one of the most horrible forms of capital punishment in history. Since his body was human, he would feel everything at least as intensely as we would.
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Could it be that Jesus is on his way To die there in the garden and prays to the father to save him there and then from that moment so he can go To the cross and die for the humanity. Like the utter most test from the father: are the son willing To die there and go To the father without saving the humanity if that is the fathers will. Obidience is better than sacrifice. Are he ready To put the father before the creation just as Abraham put God before Isak and the father was ready To give his son for the humanity. And then the father sees that Jesus is perfekted To save us all. This harmonice With hebr 5:7-9 were it says that Jesus was saved from death as his prayers were answered but he was newer saved from the death on the cross and the three night and days in grave. So what he prays for in the garden To be spare from could not be the death on the cross but that he is on his way To die there in the garden. And Jesus knows that if he dies there in the garden he can not save us. He has longed To save us in all eternity and prays the father To save him in the garden so he can save us on the cross. But is ready To obey his father even if it means not To save us. This was the ultimate test for the son in flesh in order To see if the son is puts the father before us. And this is the model for us, that we also has To come To the place were we are tests if we are ready To put the father before our lives, ministry, family and even our own calling that God has given us. Nothing is more imported for God then we putting him and his will before everything in our life just as the Son did in the gethsemane garden
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I think Christ feared seperation from the father for a season, "father why have you forsaken me" the thought of being seperated from the father caused emotional stress and hematidrosis. "He who knew no sin, became sin for us" sin was about to seperate him from the father. The father "loves a sinner but hates sin"....and Christ sin for US