score:3
Red circle indicates where 36-44 Nathan Road is. From airport, walk to the bus terminus to town. It's to the very right of arrival hall after immigration and customs. Take Bus Route A21 towards Hung Hom MTR Station and get off at Middle Road stop (circled blue). Then walk back a block.
A21 belongs to a series of bus routes dedicated for airport connection. Its fleet of buses comes with luggage rack. The bus trip costs HKD$33. Prepare exact fare or use an Octopus Card.
I recommend against taking the MTR (except Airport Express) with heavy luggages. A bag or two is fine; taking MTR with heavy luggages in evening rush hour is asking for trouble.
Alternative route for cheaper fare; uses MTR:
Upvote:2
Unless you absolutely need to take a bus, the best path is by the MTR.
Take the Airport Express to Hong Kong.
Walk to Central (it is a relatively long walk, but all indoors with moving walkways).
Take the Tsuan Wan Line to Tsim Sha Tsui.
Upvote:3
Another option would be to take the Airport Express to Kowloon and take the complimentary shuttle bus to TST. There are three such buses, K3, K4 and K5, for different parts of TST (because it's a busy and crowded region). Find out which one goes closest to your destination: bus info.